Endocrine Abstracts

BACKGROUND: Patients with dyspepsia are treated with proton pump inhibitors (PPIs) which reduce acid secretion and therefore give rise to a secondary hypergastrinaemia. Gastrinomas are a rare cause of dyspepsia diagnosed on the basis of a raised fasting gastrin measurement. Therefore, when screening patients with dyspepsia for a gastrinoma, PPIs must be withdrawn for 2 weeks, prior to the measurement of fasting gastrin levels to ensure that fasting gastrin levels are back to b...